Elevated creatinine levels in the blood can indicate impaired kidney function, as creatinine is a waste product produced by muscle metabolism and normally filtered out by the kidneys. When kidney function declines, creatinine builds up in the bloodstream instead of being excreted in the urine. This condition is often assessed through blood tests, and elevated creatinine levels can be a sign of various kidney-related issues, including chronic kidney disease, acute kidney injury, or glomerulonephritis. Additionally, factors such as dehydration, high muscle mass, or certain medications can also affect creatinine levels. Accurate diagnosis typically requires a comprehensive evaluation, including additional tests like urine analysis, imaging studies, and sometimes a kidney biopsy to determine the underlying cause and severity of kidney impairment. Managing elevated creatinine often involves treating the root cause, which may include controlling blood pressure, managing diabetes, adjusting medications, and in severe cases, considering dialysis or other interventions to support kidney function. Regular monitoring and timely treatment are crucial to preventing further kidney damage and maintaining overall health.